Batavia and ChromaTan receive NIIMBL grant to integrate column-free continuous chromatography into HIP-Vax® manufacturing platform for AAV 

Batavia and ChromaTan receive NIIMBL grant to integrate column-free continuous chromatography into HIP-Vax® manufacturing platform for AAV 

Woburn, MA, April 10, 2024 — Batavia Biosciences, a leading contract development and manufacturing organization, is excited to announce a new alliance with ChromaTan, Inc.  for the development and integration of BioRMB™ (formerly known as Continuous Countercurrent Tangential Chromatography or CCTC) technology into Batavia’s AAV HIP-Vax® manufacturing platform. This project further highlights Batavia’s commitment to improve AAV manufacturing, while reducing manufacturing costs and optimize the environmental footprint of biopharmaceuticals through process intensification.

Recombinant adeno-associated virus (rAAV) vectors are spearheading the development of next generation treatments to cure debilitating and life-threatening disorders. However, demand for rAAV is exceeding its production capacity, threatening to become a bottleneck in the treatment of large patient groups.

Continuous chromatography has been shown to greatly contribute to the intensification of manufacturing processes for monoclonal antibodies. Yet, similar applications for rAAV are still lacking. As a leading CDMO, Batavia Biosciences expects to increase its rAAV production capacity and to further reduce the associated cost of goods through integration of ChromaTan’s BioRMBTM – a novel column-free real moving bed continuous chromatography platform – into Batavia’s proprietary HIP-Vax® manufacturing platform.

“The promise of next generation platforms both upstream and downstream in the field of gene therapy is very powerful for multiple reasons such as improvements in manufacturability, process economics, improved recovery and product quality. This exciting partnership enabled by NIIMBL, will empower us to take that idea a step further – by directly integrating these hyper efficient next generation platforms we have the potential to transform rAAV manufacturing as we know it” says Oleg Shinkazh, Chief Technical officer at Chromatan.

Peter Abbink, Managing Director at Batavia Biosciences, Inc., adds: “At Batavia, we continuously seek innovative solutions to fuel our mission to enhance the accessibility and availability of critical life-changing treatments. We are privileged to have the backing of NIIMBL and are thrilled to embark on a productive partnership with ChromaTan on this endeavor.”

This project was developed with an award from the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) and financial assistance from the U.S. Department of Commerce, National Institute of Standards and Technology (70NANB21H086).

Low-cost viral vector manufacturing

High-throughput screening for viral vectors

Viral vector manufacturing

Maximizing protein expression