STEP® technology

Maximizing Protein Expression

To enable the rapid generation of stable protein or antibody expressing CHO cell lines, we have developed an affordable and complete package of services and technologies.

STEP®-mAb for monoclonal antibodies

For monoclonal antibodies, we offer a full services package including cell line generation, process development and manufacturing, marketed as STEP®-mAb.

Cell Line Generation

For cell line generation we use the CHO-GS expression system developed by Horizon Discovery. CHO-GS expression systems are the industry’s standard to optimize costs and accelerate production processes. They enable rapid identification of clones expressing high levels of monoclonal antibody during development of a stable cell line. The affordable and flexible licensing terms of the technology from Horizon Discovery facilitate access to this high-performance cell line to meet client demands.

Combining Technology & Experience

A comprehensive cell line history and a clear intellectual property (IP) position ensure freedom of operation in biotherapeutic production. Over 50 commercial licenses (and many more pending) prove the success and wide acceptance of this offering. At least five successful Investigational New Drug (IND) filings have enabled clients to progress to clinical trial demonstrating regulatory compliance.

We are in the unique position to combine this proven technology with extensive experience in cell line generation and development of robust production and purification processes. Therefore, you can rely on us to take on any challenge associated with monoclonal antibody production on CHO cells.

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Low-cost viral vector manufacturing

High-throughput screening for viral vectors

Viral vector manufacturing

Thermostable viral envelope protein formulation

Maximizing protein expression